Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers

Anion Carriers of Mitochondrial Membranes

A Systems View of the Differences between APOE ε4 Carriers and Non-carriers in Alzheimer’s Disease

APOE ε4 is the strongest genetic risk factor for late-onset Alzheimer's disease (AD) and accounts for 50-65% of late-onset AD. Late-onset AD patients carrying or not carrying APOE ε4 manifest many clinico-pathological distinctions. Thus, we applied a weighted gene co-expression network analysis to identify specific co-expression modules in AD based on APOE ε4 stratification. Two specific module...

Role of Mitochondrial Carriers in Metabolic Engineering

Gennaro Agrimi1,2*, Annamaria Russo1,2 and Maria Antonietta Ricci1,2 1Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via Orabona 4, 70125 Bari, Italy 2CIRCC Interuniversity Consortium Chemical Reactivity and Catalysis, Via Celso Ulpiani 27, 70126 Bari, Italy *Corresponding author: Gennaro Agrimi, Assistant professor, Department of Biosciences, Biotechnologi...

No differences in brain microstructure between young KIBRA-C carriers and non-carriers

KIBRA rs17070145 polymorphism is associated with variations in memory function and the microstructure of related brain areas. Diffusion kurtosis imaging (DKI) as an extension of diffusion tensor imaging that can provide more information about changes in microstructure, based on the idea that water diffusion in biological tissues is heterogeneous due to structural hindrance and restriction. We u...

Comparison of human solute carriers.

Solute carriers are eukaryotic membrane proteins that control the uptake and efflux of solutes, including essential cellular compounds, environmental toxins, and therapeutic drugs. Solute carriers can share similar structural features despite weak sequence similarities. Identification of sequence relationships among solute carriers is needed to enhance our ability to model individual carriers a...